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You searched for: subject:"cell biology"
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[texts]Cytoplasmic nanojunctions between lysosomes and sarcoplasmic reticulum are required for specific calcium signaling - Nicola Fameli
We demonstrate how nanojunctions between lysosomes and sarcoplasmic reticulum (L-SR junctions) serve to couple lysosomal activation to regenerative, ryanodine receptor-mediated cellular calcium (Ca2+) waves. In pulmonary artery smooth muscle cells (PASMCs) nicotinic acid adenine dinucleotide phosphate (NAADP) may trigger increases in cytoplasmic Ca2+ via L-SR junctions, in a manner that requires initial Ca2+ release from lysosomes and subsequent Ca2+-induced Ca2+ release (CICR) via ryanodine rec...
Keywords: Cell Biology
Downloads: 2
[texts]Choosing an appropriate modelling framework for analysing multispecies co-culture cell biology experiments - Deborah C Markham
In vitro cell biology assays play a crucial role in informing our understanding of the migratory, proliferative and invasive properties of many cell types in different biological contexts. While mono-culture assays involve the study of a population of cells composed of a single cell type, co-culture assays study a population of cells composed of multiple cell types (or subpopulations of cells). Such co-culture assays can provide more realistic insights into many biological processes including ti...
Keywords: Cell Biology
Downloads: 2
[texts]MicroRNAs Regulate the Wnt/Ca2+ Signaling Pathway to Promote the Secretion of Insulin in Pancreatic Nestin-Positive Progenitor Cells - Chunyu Bai
MicroRNAs (miRNAs) are small noncoding RNAs that bind to the 3?-UTR of mRNAs and function mainly in post-transcriptional regulation. MiRNAs have been implicated to play roles in organ development, including that of the pancreas. Many miRNAs, such as miR-375, miR-124, miR-7, miR-21 and miR-221, have been shown to regulate insulin production as well as insulin secretion. However, it is not known whether miRNAs can regulate insulin secretion via the control of intracellular Ca2+ in pancreatic beta ...
Keywords: Cell Biology
Downloads: 4
[texts]Journey to the Center of the Mitochondria Guided by the Tail Anchor of Protein Tyrosine Phosphatase 1B - Julia Fueller
The canonical protein tyrosine phosphatase PTP1B has traditionally been considered to exclusively reside on the endoplasmic reticulum (ER). Using confocal microscopy, we show that endogenous PTP1B actually exhibits a higher local concentration at the mitochondria in all mammalian cell lines that we tested. Fluorescently labeled chimeras containing full-length PTP1B or only its 35 amino acid tail anchor localized identically, demonstrating the complete dependence of PTP1Bs subcellular partitionin...
Keywords: Cell Biology
Downloads: 7
[texts]Using Polysome Isolation with Mechanism Alteration to Uncover Transcriptional and Translational Dynamics in Key Genes - Bradly Alicea
What does it mean when we say a cell?s biochemistry is regulated during changes to the phenotype? While there are a plethora of potential mechanisms and contributions to the final outcome, a more tractable approach is to examine the dynamics of mRNA. This way, we can assess the contributions of both known and unknown decay and aggregation processes for maintaining levels of gene product on a gene-by-gene basis...
Keywords: Cell Biology
Downloads: 4
[texts]The HVCN1 channel conducts protons into the phagocytic vacuole of neutrophils to produce a physiologically alkaline pH - Adam P Levine
Activation of the NADPH oxidase (NOX2) of the phagocytic vacuole of neutrophils is essential for innate immunity. Sustained activity of the oxidase requires that charge movements across the membrane are balanced. A role for the proton channel, HVCN1, has been proposed but not proven. Using the ratiometric pH indicator SNARF, introduced into the cytosol and separately into the vacuole coupled to Candida , we used confocal microscopy to measure changes in pH in these two compartments in human and ...
Keywords: Cell Biology
Downloads: 4
[texts]Mpl expression on megakaryocytes and platelets is dispensable for thrombopoiesis but essential to prevent myeloproliferation - Ashley P Ng
Thrombopoietin (TPO) acting via its receptor Mpl is the major cytokine regulator of platelet number. To precisely define the role of specific hematopoietic cells in TPO dependent hematopoiesis, we generated mice that express the Mpl receptor normally on stem/progenitor cells but lack expression on megakaryocytes and platelets ( MplPF4cre/PF4cre . MplPF4cre/PF4cre mice displayed profound megakaryocytosis and thrombocytosis with a remarkable expansion of megakaryocyte-committed and multipotential ...
Keywords: Cell Biology
Downloads: 14
[texts]Filament formation by metabolic enzymes is a specific adaptation to an advanced state of cellular starvation - Ivana Petrovska
One of the key questions in biology is how the metabolism of a cell responds to changes in the environment. In budding yeast, starvation causes a drop in intracellular pH, but the functional role of this pH change is not well understood. Here, we show that the enzyme glutamine synthetase (Gln1) forms filaments at low pH and that filament formation leads to enzymatic inactivation. Filament formation by Gln1 is a highly cooperative process, strongly dependent on macromolecular crowding, and involv...
Keywords: Cell Biology
Downloads: 2
[texts]Methods to study toxic transgenes in C. elegans: an analysis of protease-dead separase in the C. elegans embryo - Diana M Mitchell
We investigated whether the protease activity of separase, which is required for chromosome segregation, is also required for its other roles during anaphase in C. elegans given that non-proteolytic functions of separase have been identified in other organisms. We find that expression of protease-dead separase is dominant-negative in C. elegans embryos. The C. elegans embryo is an ideal system to study developmental processes in a genetically tractable system...
Keywords: Cell Biology
Downloads: 5
[texts]OPPOSING MICROTUBULE MOTORS CONTROL MOTILITY, MORPHOLOGY, AND CARGO SEGREGATION DURING ER-TO-GOLGI TRANSPORT. - Anna K Brown
We recently demonstrated that dynein and kinesin motors drive multiple aspects of endosomal function in mammalian cells. These functions include driving motility, maintaining morphology (notably through providing longitudinal tension to support vesicle fission), and driving cargo sorting. Microtubule motors drive bidirectional motility during traffic between the endoplasmic reticulum (ER) and Golgi...
Keywords: Cell Biology
Downloads: 9
[texts]TCF7L2 is a master regulator of insulin production and processing - Yuedan Zhou
Although variants in the T-cell factor 7-like 2 gene (TCF7L2) confer the strongest risk of type 2 diabetes (T2D) by presumed effects on islet function, the underlying mechanisms are not well understood. We have identified TCF7L2-target genes and described the regulatory network downstream of TCF7L2 responsible for its effect on insulin secretion in rodents and human pancreatic islets. ISL1 is a direct target of TCF7L2 and regulates proinsulin production and processing via MAFA, PDX1, NKX6.1, PCS...
Keywords: Cell Biology
Downloads: 4
[texts]Fluorescent sensors for activity and regulation of the nitrate transceptor CHL1/NRT1.1 and oligopeptide transporters - Cheng Hsun Ho
To monitor nitrate and peptide transport activity in vivo, we converted the dual-affinity nitrate transceptor CHL1/NRT1.1/NPF6.3 and four related oligopeptide transporters PTR1, 2, 4 and 5 into fluorescence activity sensors (NiTrac1, PepTrac). Substrate addition to yeast expressing transporter fusions with yellow fluorescent protein and mCerulean triggered substrate-dependent donor quenching or resonance energy transfer...
Keywords: Cell Biology
Downloads: 5
[texts]Massively calcified endosomal death (MCED) of endothelial cells - Larry Weisenthal
We have discovered a novel and specific mechanism of endothelial cell death.We refer to this novel death mechanism as massively calcified endosomal death, or MCED. Exposure of endothelial cells to non-specific toxins or other physical stresses induces death by traditional apoptotic and non-apoptotic mechanisms, common to most different types of cells. In contrast, exposure of endothelial cells (but not other types of nucleated cells) to specific insults, such as oxidized pathogenic lipids (e.g...
Keywords: Cell Biology
Downloads: 6
[texts]TACC3-ch-TOG track the growing tips of microtubules independently of clathrin and Aurora-A phosphorylation - Cristina Gutiérrez-Caballero
The interaction between TACC3 (transforming acidic coiled coil protein 3) and the microtubule polymerase ch-TOG (colonic, hepatic tumor overexpressed gene) is evolutionarily conserved. Loading of TACC3–ch-TOG onto spindle microtubules requires the phosphorylation of TACC3 by Aurora-A kinase and the subsequent interaction of TACC3 with clathrin to form a microtubule binding surface. Whether there is a pool of TACC3–ch-TOG that is independent of clathrin in human cells, and what is the functio...
Keywords: Cell Biology
Downloads: 12
[texts]Products of the Parkinson's-disease related glyoxalase DJ-1, D-lactate and glycolate, support mitochondrial membrane potential and neuronal survival - Yusuke Toyoda
Parkinson's disease is associated with mitochondrial decline in dopaminergic neurons of the substantia nigra. One of the genes, DJ- 1/PARK7, linked with the onset of Parkinson’s disease, belongs to a novel glyoxalase family and influences mitochondrial activity. It has been assumed that glyoxalases fulfill this task by detoxifying aggressive aldehyde by-products of metabolism. Here we show that supplying either D-lactate or glycolate, products of DJ-1, rescues the requirement for the enzyme in...
Keywords: Cell Biology
Downloads: 3
[texts]Artificially inducing close apposition of endoplasmic reticulum and mitochondria induces mitochondrial fragmentation. - Victoria J Miller
Cycles of mitochondrial fission and fission are essential for normal cell physiology. Defects in the machinery controlling these processes lead to neurodegenerative disease. While we are beginning to understand the machinery that drives fission, our knowledge of the spatial and temporal control of this event is lacking. Here we use a rapamycin-inducible heterodimerization system comprising both ER and mitochondrial transmembrane components to bring the ER membrane into close physical proximity w...
Keywords: Cell Biology
Downloads: 5
[audio]GENETICS 8/27
Genetics class with Dr. Schau at North Park University
Keywords: genetics; cell biology
Downloads: 60
[movies]Cell locomotion II
Cell biology sequences. Tumour cells - MCIM shot 1 frame every 10 seconds one frame every 6 seconds. Vertical longitudinal section of leading edge graphi illustration. Tumour cells illustration S180. Cells in culture. Macrophages
Keywords: Cell Biology; Fibroblasts
Downloads: 30
[texts]Methods in Cell Biology - Mark F. Wiser
Contents: MICROSCOPY, SPECTROPHOTOMETRY, FLUORESCENCE, RADIOCHEMISTRY, pH AND BUFFERS, CENTRIFUGATION, INTRODUCTION TO PROTEINS, DIFFERENTIAL PRECIPITATION OF PROTEINS, MEMBRANES AND DETERGENTS, ELECTROPHORESIS, PROTEIN PURIFICATION, MMUNIZATION, IMMUNOASSAYS, NUCLEIC ACID STRUCTURE AND ISOLATION, DNA SEQUENCING AND ANALYSIS, POLYMERASE CHAIN REACTION and more. Lecture Notes Collection FreeScience.info ID585 Obtained from http://www.tulane.edu/~wiser/methods/notes.pdf http://www.freescience.info...
Keywords: Methods in Cell Biology
Downloads: 125
[movies]biology as level, the cell - Mr Gavan
revision clip for biology students
Keywords: cell biology as level
Downloads: 999
[texts]Scientific Questions for Scientific Thinkers - Sivashanmugam
What will you do if no thing has divisibility, comparability, connectivity, disturbability, reorderability, substitutability, and satisfiability?
Keywords: cell biology; Molecular biology; Biochemistry
Downloads: 57
[movies]Failure of contact inhibition
S180 Fibroblasts shot in time-lapse, 1 frame every 10 seconds. Sideways collisions. Cells on agar.
Keywords: Embryonic development; Embryonic Structures; Cell Biology; Fibroblasts
Downloads: 11
[movies]Contact inhibition of locomotion
The opening sequences are of chick heart fibroblasts shot one frame every 5 seconds (in black and white). Sequences follow of contact and then monolayer cell formation. Collision between cells etc shot in time-lapse.
Keywords: Embryonic development; Embryonic Structures; Cell Biology; Fibroblasts
Downloads: 8
[movies]Cell locomotion I
The opening sequences are of chick heart fibroblasts migration. There is a graphic illustration of a vertical longitudinal section of leading edge. Mouse muscle fibroblasts.
Keywords: Embryonic development; Embryonic Structures; Cell Biology; Fibroblasts
Downloads: 8
[texts]Cellular pathology [electronic resource] : as based upon physiological and pathological histology twenty lectures delivered in the Pathological Institute of Berlin during the months of February, March, and April, 1858 - Virchow, Rudolf, 1821-1902
Translation of: Die Cellularpathologie. 2. neu durchgesehene Aufl. Berlin: A. Hirschwald, 1859
Keywords: Pathology, Cellular; Histology; Cell Biology; Pathology
Downloads: 2
[texts]Die Zelle und die Gewebe : Grundzüge der Allgemeinen Anatomie und Physiologie - Hertwig, Oscar, 1849-1922
Garrison no. 556
Keywords: Cells; Anatomy; Physiology; Cell Biology; Histology
Downloads: 216
[movies]Cells in culture
The opening sequences are of normal cell behaviour in colour. Isolated cells showing active movement. Streaming of packed cells - movement. Contact inhibition. Mouse muscle fibroblasts. Abnormal behaviour of tumour cells. Normal behaviour of cells. The End credit.
Keywords: Embryonic development; Embryonic Structures; Cell Biology; Fibroblasts
Downloads: 22
[unknown]Wiki - Computational Cell Biology
Computational Cell Biology dumped with WikiTeam tools.
Keywords: wiki; wikiteam; MediaWiki; Computational Cell Biology; raquellus_ccb; unknowncopyright
Downloads: 5
[movies]Cultivation of living tissue Part 3
Part 3 passes from normal tissue growth to cancer. Older cells are shown at their degenerative stage. Motile cells are active against degenerative ones. Reaction after radium a clock is present in the top right of the frame to illustrate the pasing of time. 00:06:40 approx an intertitle explains that the scientific part of the film was photographed by the late Dr. R. G. Canti when he was investigating the effect of radium and x-rays on living tissues...
Keywords: Microscopy; Embryonic development; Embryonic Structures; Cell Biology; Fibroblasts; Neoplasms
Downloads: 6
[movies]Cultivation of living tissue Part 2
Part 2 shows organised growth a rabbit ovum, chick embryo (clearly illustrating cell division) and the development of the thigh bone of the chick. Some sequences show a clock in the corner to illustrate time passing. Histological sections of the femur are shown. An indicator is top right of the frame with the relevant day the sequences were shot. End of Part 2.
Keywords: Microscopy; Embryonic development; Embryonic Structures; Cell Biology; Fibroblasts
Downloads: 7
[movies]Cultivation of living tissue Part 1
Tissue culture living cells cultivated in vitro shown in time-lapse. There is a long explanatory intertitle at the beginning which includes how the images are captured. This is then demonstrated. Embryonic cells are shown in time-lapse (speeded up 960 times). Wandering cells and fibroblasts cell division. There is a hand drawing of a fibroblast, with annotations. Daughter cells. Chromosome arrangement...
Keywords: Microscopy; Embryonic development; Embryonic Structures; Cell Biology; Fibroblasts
Downloads: 7
[movies]Chick heart fibroblasts
Chick heart fibroblasts cells migrating in time-lapse and close-up. High power imagery of leading lamella.
Keywords: Microscopy; Embryonic development; Embryonic Structures; Cell Biology; Fibroblasts
Downloads: 15
[texts]Global Stem Cells Market By Application ( Regenerative Medicine, Drug Discovery And Development), By Technology, By Product To Reach USD 170.15 Billion By 2020 - Grand View Research
The stem cells technology market was valued at USD 12.88 billion in 2013 and is expected to grow at a CAGR of over 12.0% during the forecast period. This market was dominated by the cell acquisitions technology segment in terms of share in 2013 owing to the fact that this technology serves as the foremost step to process involving stem cells culture. The global stem cell acquisition technology market is expected to reach USD 10.88 billion by 2020, growing at a CAGR of over 14.0% over the next si...
Keywords: #Stem Cells Market; #Stem Cells; #Developmentalbiology; #Cloning; #Cell biology; #Biotechnology; #Induced stemcells; #GrandViewResearch
[texts]Cell. Biology. Lecture. 01. Dr. Reham. Uploaded. By. Denta Youth. Technical. Support. Team
Cell. Biology. Lecture. 01. Dr. Reham. Uploaded. By. Denta Youth. Technical. Support. Team
Keywords: Cell. Biology. Lecture. 01. Dr. Reham. Uploaded. By. Denta Youth. Technical. Support. Team
Downloads: 346
[texts]Marian E. Koshland, 1921-1997 : oral history transcript : retrospectives on a life in academic science, family, and community activities / 2003 - Bancroft Library. Regional Oral History Office

Keywords: Koshland, Marian Elliott; Koshland family; University of California, Berkeley. Dept. of Molecular and Cell Biology; Immunologists -- California Berkeley; Biology -- Study and teaching California Berkeley; Immunology -- United States
Downloads: 1,320
[texts]Proceedings of the Indiana Academy of Science (Volume 100:3-4 1991) - Indiana Academy of Science
These are the papers from the I.A.S. conference as well as the committee meeting minutes.
Keywords: Indiana Academy of Science; life sciences; science; conference proceedings; botany; cell biology; entomology; geology; physics; plant taxonomy; science education; history of science; atmospheric science; chemistry; ecology; soil science; zoology; microbiology
Downloads: 177
[texts]Proceedings of the Indiana Academy of Science (Volume 100:1-2 1991) - Indiana Academy of Science
These are the papers from the I.A.S. conference as well as the committee meeting minutes.
Keywords: Indiana Academy of Science; life sciences; science; conference proceedings; botany; cell biology; entomology; geology; physics; plant taxonomy; science education; history of science; atmospheric science; chemistry; ecology; soil science; zoology; microbiology
Downloads: 205
[texts]Proceedings of the Indiana Academy of Science (Volume 103:1-2 1994) - Indiana Academy of Science
These are the papers from the I.A.S. conference as well as the committee meeting minutes.
Keywords: Indiana Academy of Science; life sciences; science; conference proceedings; botany; cell biology; entomology; geology; physics; plant taxonomy; science education; history of science; atmospheric science; chemistry; ecology; soil science; zoology; microbiology
Downloads: 308
[texts]Proceedings of the Indiana Academy of Science (Volume 34 1924) - Indiana Academy of Science
These are the papers from the I.A.S. conference as well as the committee meeting minutes.
Keywords: Indiana Academy of Science; life sciences; science; conference proceedings; botany; cell biology; entomology; geology; physics; plant taxonomy; science education; history of science; atmospheric science; chemistry; ecology; soil science; zoology; microbiology
Downloads: 280
[texts]Proceedings of the Indiana Academy of Science (Volume 106:3-4 1997) - Indiana Academy of Science
These are the papers from the I.A.S. conference as well as the committee meeting minutes.
Keywords: Indiana Academy of Science; life sciences; science; conference proceedings; botany; cell biology; entomology; geology; physics; plant taxonomy; science education; history of science; atmospheric science; chemistry; ecology; soil science; zoology; microbiology
Downloads: 340
[texts]Proceedings of the Indiana Academy of Science (Volume 101:1-2 1992) - Indiana Academy of Science
These are the papers from the I.A.S. conference as well as the committee meeting minutes.
Keywords: Indiana Academy of Science; life sciences; science; conference proceedings; botany; cell biology; entomology; geology; physics; plant taxonomy; science education; history of science; atmospheric science; chemistry; ecology; soil science; zoology; microbiology
Downloads: 226
[texts]Proceedings of the Indiana Academy of Science (Volume 46 1936) - Indiana Academy of Science
These are the papers from the I.A.S. conference as well as the committee meeting minutes.
Keywords: Indiana Academy of Science; life sciences; science; conference proceedings; botany; cell biology; entomology; geology; physics; plant taxonomy; science education; history of science; atmospheric science; chemistry; ecology; soil science; zoology; microbiology
Downloads: 308
[texts]Proceedings of the Indiana Academy of Science (Volume 115:2 2006) - Indiana Academy of Science
These are the papers from the I.A.S. conference as well as the committee meeting minutes.
Keywords: Indiana Academy of Science; life sciences; science; conference proceedings; botany; cell biology; entomology; geology; physics; plant taxonomy; science education; history of science; atmospheric science; chemistry; ecology; soil science; zoology; microbiology
Downloads: 274
[texts]Proceedings of the Indiana Academy of Science (Volume 108/109: 1-4 1999/2000) - Indiana Academy of Science
These are the papers from the I.A.S. conference as well as the committee meeting minutes.
Keywords: Indiana Academy of Science; life sciences; science; conference proceedings; botany; cell biology; entomology; geology; physics; plant taxonomy; science education; history of science; atmospheric science; chemistry; ecology; soil science; zoology; microbiology
Downloads: 349
[texts]Proceedings of the Indiana Academy of Science (Volume 111:1 2002) - Indiana Academy of Science
These are the papers from the I.A.S. conference as well as the committee meeting minutes.
Keywords: Indiana Academy of Science; life sciences; science; conference proceedings; botany; cell biology; entomology; geology; physics; plant taxonomy; science education; history of science; atmospheric science; chemistry; ecology; soil science; zoology; microbiology
Downloads: 192
[texts]Proceedings of the Indiana Academy of Science (Volume 39 1929) - Indiana Academy of Science
These are the papers from the I.A.S. conference as well as the committee meeting minutes.
Keywords: Indiana Academy of Science; life sciences; science; conference proceedings; botany; cell biology; entomology; geology; physics; plant taxonomy; science education; history of science; atmospheric science; chemistry; ecology; soil science; zoology; microbiology
Downloads: 439
[texts]Proceedings of the Indiana Academy of Science (Volume 52 1942) - Indiana Academy of Science
These are the papers from the I.A.S. conference as well as the committee meeting minutes.
Keywords: Indiana Academy of Science; life sciences; science; conference proceedings; botany; cell biology; entomology; geology; physics; plant taxonomy; science education; history of science; atmospheric science; chemistry; ecology; soil science; zoology; microbiology
Downloads: 359
[texts]Proceedings of the Indiana Academy of Science (Volume 37 1927) - Indiana Academy of Science
These are the papers from the I.A.S. conference as well as the committee meeting minutes.
Keywords: Indiana Academy of Science; life sciences; science; conference proceedings; botany; cell biology; entomology; geology; physics; plant taxonomy; science education; history of science; atmospheric science; chemistry; ecology; soil science; zoology; microbiology
Downloads: 430
[texts]Proceedings of the Indiana Academy of Science (Volume 96 1986) - Indiana Academy of Science
These are the papers from the I.A.S. conference as well as the committee meeting minutes.
Keywords: Indiana Academy of Science; life sciences; science; conference proceedings; botany; cell biology; entomology; geology; physics; plant taxonomy; science education; history of science; atmospheric science; chemistry; ecology; soil science; zoology; microbiology
Downloads: 1,088
[texts]Proceedings of the Indiana Academy of Science (Volume 49 1939) - Indiana Academy of Science
These are the papers from the I.A.S. conference as well as the committee meeting minutes.
Keywords: Indiana Academy of Science; life sciences; science; conference proceedings; botany; cell biology; entomology; geology; physics; plant taxonomy; science education; history of science; atmospheric science; chemistry; ecology; soil science; zoology; microbiology
Downloads: 253
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